Organometallic compounds to modulate intracellular chemistry

Place: conference room, IMDEA Nanociencia.

Abstract:

Organometallic and coordination bonds have accessible energy dynamics that make them attractive tools to react with cellular components. Metal-mediated chemistry of organometallics can be activated or inhibited by the right choice of metal and its surrounding ligands. It is the fine balance between reactivity and inertness that gives metal complexes extraordinary potential in the crowded intracellular environment.
I will introduce half-sandwich compounds featuring iridium, rhodium, osmium, and ruthenium. Structurally, these compounds include a tether ring that can open and close, a switch-like intramolecular mechanism that provides controlled access to the metal's chemistry inside human cells.
Some of the complexes I will present rank among the most potent metal-based compounds to date against cancer cells. I will show our efforts to understand the molecular basis that drive intracellular reactivity of some of our complexes. I will also show an example of how we attempt to map the distribution of our metal-complexes inside cells, as we try to fully illustrate their intracellular fate. Finally, I will give an example on how we try to harness organometallic chemistry in the intracellular space.

Relevant publications:
• AC Carrasco, V Rodríguez‐Fanjul, A Habtemariam, AM Pizarro. J. Med. Chem. 2020, 63, 4005-4021.
• JJ Conesa, AC Carrasco, V Rodríguez‐Fanjul, Y Yang, JL Carrascosa, P Cloetens, E Pereiro, AM Pizarro. Angew. Chem. Int. Ed. 2020, 59, 1270-1278.
• S Infante-Tadeo, V Rodríguez-Fanjul, A Habtemariam, AM Pizarro. Chem. Sci. 2021, 12, 9287–9297.
• S Infante-Tadeo, V Rodríguez-Fanjul, CC Vequi-Suplicy, AM Pizarro. Inorg. Chem. 2022, 61, 18970−18978.
• C Cardozo, AM Pizarro. Chem. Eur. J. 2024, 30, e202402799

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